Beso Wellness & Beauty offers the P-Shot 100 in Phoenix and Scottsdale — our most comprehensive single-session men’s sexual health protocol. The P-Shot 100 combines two clinically supported regenerative treatments in one visit: the P-Shot (Platelet-Rich Plasma) for tissue regeneration and growth factor signaling, plus BoCox (intracavernosal botulinum toxin) for direct smooth muscle relaxation and hemodynamic improvement. Together, they target both the structural and functional components of erectile health simultaneously.
Whether you’ve tried PRP or penile Botox separately and want the synergy of both, or you’re looking for an advanced erectile function protocol beyond PDE5 inhibitors — our clinic near Desert Ridge is one of the few in the Phoenix area offering this dual-action treatment within a medically supervised men’s health program.
Single session
Saved vs. separate
Total session
Synergy window
What Is the P-Shot 100? Understanding the Dual-Action Protocol
The P-Shot 100 is a branded combination protocol that delivers both Platelet-Rich Plasma (PRP) and 100 units of botulinum toxin type A (BoNT-A) into penile tissue in a single treatment session. The name reflects the two components: the P-Shot (PRP) plus 100 units of botulinum toxin.
Each component addresses a different mechanism in the erectile pathway:
| Component | What It Does | How It Supports Erectile Function |
|---|---|---|
| P-Shot (PRP) | Delivers concentrated growth factors from your own blood into penile tissue | Supports tissue regeneration, microvascular health, collagen remodeling, and nerve-adjacent signaling. Effects build over weeks to months. |
| BoCox (100 Units Botox) | Relaxes corporal smooth muscle by inhibiting acetylcholine and norepinephrine release | Facilitates arterial blood inflow into the erectile chambers. Creates a sustained environment of improved smooth muscle compliance for 4–6 months. |
When delivered together, PRP regenerates the tissue while botulinum toxin immediately begins optimizing the vascular mechanics. PRP and intracavernosal botulinum toxin each have independent published evidence supporting their use in erectile dysfunction. The combination is mechanistically rational — BoNT-A creates the improved vascular environment that PRP needs to deliver tissue regeneration effectively — though combination protocols have not yet been studied in randomized trials at this scale.
Why “100”?
The number refers to the 100 units of botulinum toxin type A used in the protocol — 50 units injected into each corpus cavernosum. El-Shaer et al. (Andrology, 2021) compared 50-unit and 100-unit dosing in a randomized controlled trial of vasculogenic ED; the 100-unit arm showed significant improvement in erectile function scores sustained at 6 months.
Why Botox (OnabotulinumtoxinA)?
Beso uses Botox (onabotulinumtoxinA by Allergan) — the same formulation used in the El-Shaer RCT that established the 100-unit dosing protocol. Botox has the longest clinical track record, the most established safety data, and unit-for-unit dosing consistency. Xeomin and Dysport are not interchangeable at the same unit count.
Why Combine PRP and Botulinum Toxin? The Science of Dual-Action Therapy
Erectile dysfunction is rarely caused by a single factor. In most men — particularly those with vasculogenic ED — the problem involves both structural tissue changes (damaged endothelium, reduced collagen quality, diminished microcirculation) and functional smooth muscle dysfunction (chronic over-contraction that restricts blood inflow).
Treating only one of these components leaves the other unaddressed:
| Approach | What It Addresses | What It Misses |
|---|---|---|
| PRP alone (P-Shot) | Tissue quality, growth factor signaling, microvascular health | Smooth muscle tone — if muscle is chronically contracted, regenerated tissue still can’t fill optimally |
| Botulinum toxin alone (BoCox) | Smooth muscle relaxation, arterial blood flow mechanics | Tissue quality — damaged or aged tissue may not sustain improved blood flow without regenerative support |
| PRP + BoNT-A together (P-Shot 100) | Both: tissue regeneration AND smooth muscle optimization | Addresses the most complete range of erectile physiology in a single session |
BoCox opens the door. PRP rebuilds the house.
BoCox opens the door — it relaxes smooth muscle so blood can flow in. PRP rebuilds the house — it regenerates the tissue that blood flows through. Doing both at once creates a synergistic environment where each treatment amplifies the other.
Who Is the Ideal Candidate for the P-Shot 100?
The P-Shot 100 is our premium protocol — designed for men who want the most comprehensive single-session approach to erectile health. It is particularly well-suited for:
Men with Vasculogenic ED Who Want Maximum Impact
If reduced blood flow and tissue quality are both contributing to your ED — as they are in the majority of cases — the P-Shot 100 addresses both simultaneously rather than requiring separate treatment sessions.
Men Who Are Partial Responders to PDE5 Inhibitors
If Viagra or Cialis helps somewhat but doesn’t fully restore reliable function, the P-Shot 100 targets the mechanics (smooth muscle relaxation) and the biology (tissue regeneration) that PDE5 inhibitors alone cannot fix.
Men Who Want Fewer Visits and Faster Protocol Completion
Rather than scheduling a P-Shot on one visit and BoCox on another, the P-Shot 100 delivers both in approximately 45–60 minutes in a single appointment. This is especially valuable for men with busy schedules or those traveling to our Phoenix clinic from outside the immediate area.
Men Building a Comprehensive Regenerative Protocol
Men who are also pursuing shockwave therapy or testosterone optimization often choose the P-Shot 100 as the centerpiece of their protocol — it provides the most robust tissue-level intervention in one session, which shockwave and TRT then complement from different angles.
Who Should Choose Individual Treatments Instead?
If your primary concern is sensitivity rather than erectile function, the standalone P-Shot may be sufficient. If smooth muscle dysfunction has been specifically identified as your primary issue with adequate tissue quality, standalone BoCox may be appropriate. Your Beso provider will recommend the right approach at consultation.
The P-Shot 100 Protocol — What to Expect at Beso Wellness & Beauty
Step 1 — Comprehensive Medical Consultation
Every P-Shot 100 begins with the same thorough screening as our individual protocols: ED history and pattern, medication review, vascular risk markers (A1c, blood pressure, lipid panel), hormonal assessment (testosterone, estradiol, SHBG), and candidacy evaluation. We confirm that the dual-action protocol is the right fit for your presentation — and if a different approach would serve you better, we will tell you.
Step 2 — Comfort Protocol
A medical-grade topical anesthetic is applied with adequate time for full effect — typically 20–30 minutes. We do not rush this step. Most men report that the procedure is significantly more comfortable than anticipated.
Step 3 — Blood Draw & PRP Processing
A small blood sample is collected and processed in a centrifuge to concentrate Platelet-Rich Plasma — the same process used in the standalone P-Shot. PRP is prepared and ready for injection while BoCox is being administered.
Step 4 — Dual Injection — BoCox + PRP
Your provider performs the BoCox injection first: 100 units of Botox (onabotulinumtoxinA) — 50 units per corpus cavernosum — to initiate smooth muscle relaxation. PRP is then placed into targeted tissue areas to deliver concentrated growth factors directly where regeneration is needed. The combined injection protocol takes approximately 20–30 minutes.
Step 5 — Post-Procedure Guidance
You leave with clear instructions covering timeline expectations (BoNT-A activates at 1–2 weeks, PRP remodeling at 2–8 weeks), sexual activity guidelines (typically 24–48 hours), and any adjunct recommendations for your case.
Results Timeline — When to Expect What
Because the P-Shot 100 combines two treatments with different onset timelines, the response pattern is layered:
| Timeframe | What’s Happening |
|---|---|
| Days 1–3 | Mild swelling resolves. Both treatments are in the activation phase. |
| Weeks 1–2 | BoCox activates — smooth muscle begins to relax. Some men notice improved morning erections and spontaneous engorgement as blood flow mechanics improve. |
| Weeks 2–6 | PRP proliferation phase begins overlapping with BoCox’s full effect. Most men report firmer, more reliable erections. May notice improved response to PDE5 inhibitors. |
| Weeks 6–12 | PRP remodeling phase — collagen reorganization, tissue thickening, and microvascular improvement reach peak activity. BoCox effect remains strong. Often when men report the most significant overall improvement. |
| Months 3–6 | Full clinical evaluation window. Both treatments contributing simultaneously. Many men describe this as their “best window.” |
| Months 6–12+ | BoCox gradually metabolizes (4–6 months). PRP benefits may persist longer. Many men report tissue improvements lasting well beyond the BoCox window. |
The Synergy Window — Weeks 2 to 16
The period between weeks 2 and 16 is the synergy window — when both PRP’s regenerative activity and BoCox’s smooth muscle relaxation are active simultaneously. This is the unique advantage of the P-Shot 100: it creates a sustained period where tissue is being rebuilt in an environment of optimized blood flow, maximizing the potential for both treatments.
P-Shot 100 vs. Individual Treatments — An Honest Comparison
| Feature | P-Shot Alone | BoCox Alone | P-Shot 100 (Combined) |
|---|---|---|---|
| Targets Tissue Regeneration | Yes | No | Yes |
| Targets Smooth Muscle Relaxation | No | Yes | Yes |
| Growth Factor Delivery | Yes (PRP) | No | Yes (PRP) |
| Blood Flow Optimization | Indirect (via tissue health) | Direct (via muscle relaxation) | Both direct and indirect |
| Onset of Effects | 2–8 weeks | 1–2 weeks | Layered — early + sustained |
| Duration of Benefits | Months to 1 year+ | 4–6 months | Extended — PRP may outlast BoCox |
| Sessions Required | 1 visit | 1 visit | 1 visit (both in same session) |
| Investment | $1,800 | $1,800 | $2,800 (save $800 vs. separate) |
| Best For | Sensitivity, tissue quality, mild ED | Vasculogenic ED, PDE5 non-response | Most comprehensive single-session approach |
P-Shot 100 Pricing at Beso Wellness & Beauty
| Treatment | Investment | Includes |
|---|---|---|
| P-Shot 100 (P-Shot + BoCox) | $2,800 | PRP + 100 units Botox in a single session. Consultation, blood draw, PRP processing, comfort protocol, dual injection, and post-care guidance included. Saves $800 versus booking each treatment individually. |
| P-Shot (standalone) | $1,800 | PRP-only protocol. Ideal if tissue quality or sensitivity is the primary concern. |
| BoCox (standalone) | $1,800 | Botox only. Targets smooth muscle relaxation and blood flow mechanics directly. |
Pricing subject to change — verify current pricing at time of consultation. Financing available through Cherry.
Why Choose Beso Wellness & Beauty for the P-Shot 100 in Phoenix?
CMA-Certified Provider
The P-Shot 100 at Beso is performed by Naomi Fayzulayev, FNP-C — a Cellular Medicine Association (CMA) certified provider trained directly by the organization that developed the P-Shot, P-Shot 100, and BoCox protocols. CMA certification is required to legally administer these trademarked procedures.
Whole-Man Screening
We screen vascular markers, hormonal status, and metabolic health before recommending the P-Shot 100 — because those factors determine whether the dual protocol is the right choice versus individual treatments.
Protocol Integration
The P-Shot 100 is often the centerpiece of a broader protocol. We coordinate it with shockwave therapy, TRT, and other modalities to create a cohesive, individualized men’s sexual health program.
Off-Label Transparency
Full informed consent for the botulinum toxin component, including current research status, realistic expectations, and alternatives. No hype. Honest, evidence-based guidance.
Discreet Environment
Professional, private setting with staff trained in sensitivity for men’s sexual health. All consultations and treatments are handled with complete confidentiality.
Convenient Location
Near Desert Ridge and the 101 & 51 interchange (85050), easily accessible from Scottsdale, Paradise Valley, and across the Phoenix metro.
Clinical References
- El-Shaer W, Ghanem H, Diab T, Abo-Taleb A, Kandeel W. Intra-cavernous injection of BOTOX (50 and 100 Units) for treatment of vasculogenic erectile dysfunction: Randomized controlled trial. Andrology. 2021;9(4):1166-1175. https://doi.org/10.1111/andr.13010
- Abdelrahman IFS, Raheem AA, Elkhiat Y, et al. Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial. Andrology. 2022;10(2):254-261. https://doi.org/10.1111/andr.13104
- Ghanem H, Raheem AA, AbdelRahman IFS, et al. Botulinum Neurotoxin and Its Potential Role in the Treatment of Erectile Dysfunction. Sex Med Rev. 2018;6(1):135-142. https://doi.org/10.1016/j.sxmr.2017.07.008
Your Providers
Naomi Fayzulayev
FNP-C · Founder & Medical Director
Leah Fayzulayev
BSN, RN · Aesthetic Nurse Injector
Frequently Asked Questions — P-Shot 100 in Phoenix & Scottsdale
What is the P-Shot 100?
How much does the P-Shot 100 cost in Phoenix?
The P-Shot 100 at Beso Wellness & Beauty is $2,800. This includes the consultation, blood draw, PRP processing, comfort protocol, dual injection (PRP + 100 units Botox), and post-care guidance. It saves $800 compared to booking a P-Shot ($1,800) and BoCox ($1,800) as separate treatments.
Is the P-Shot 100 better than the P-Shot alone?
It depends on your presentation. The P-Shot 100 targets both tissue quality and smooth muscle mechanics, making it the more comprehensive approach. For men whose ED involves vascular and tissue components — which is the majority — the combination provides broader coverage. Men whose primary concern is sensitivity alone may do well with the standalone P-Shot. Your provider will recommend the best approach at consultation.
Is the P-Shot 100 painful?
We use the same thorough topical numbing protocol as our individual treatments. Most men report that both injections are brief and significantly more comfortable than anticipated. The total procedure time after numbing is approximately 20–30 minutes.
How long do P-Shot 100 results last?
BoCox effects typically last 4–6 months. PRP benefits may persist longer — many men report tissue improvements lasting beyond the BoCox window. The "synergy window" where both treatments are active simultaneously is approximately weeks 2 through 16. Repeat treatment timing is based on your individual response.
Can I use Viagra or Cialis with the P-Shot 100?
Yes. Both components of the P-Shot 100 work through different mechanisms than PDE5 inhibitors. Many men find that the P-Shot 100 improves their response to Cialis or Viagra, and some are able to reduce their medication dose over time.
Is the P-Shot 100 FDA approved?
The PRP component uses your own blood processed using FDA-cleared kits. Botulinum toxin type A is FDA-approved for multiple medical indications; its use in erectile dysfunction is off-label — a legal, physician-directed application supported by published clinical research. Both components have established safety profiles.
What is the difference between the P-Shot 100 and Comprehensive ED Therapy?
The P-Shot 100 is a single-session dual-injection protocol. Comprehensive ED Therapy is a structured, multi-visit program that may include P-Shot 100, shockwave therapy, hormonal optimization, medical management, and ongoing monitoring — designed for men with more complex or longstanding erectile dysfunction.
When can I have sex after the P-Shot 100?
Most men can resume sexual activity within 24–48 hours. However, the full effects build over 1–6 weeks as BoCox activates and PRP remodeling begins. Your provider will give specific guidance at the time of treatment.
Is the P-Shot 100 safe for diabetic men?
Men with well-controlled diabetes can often be candidates. Vasculogenic ED is extremely common in diabetic men, and the P-Shot 100 targets both the tissue degradation and smooth muscle dysfunction that diabetes accelerates. Outcomes depend on A1c, vascular status, and overall metabolic health.
Related Treatments at Beso Wellness & Beauty
BoCox (Penile Botulinum Toxin) Phoenix
Shockwave Therapy for ED Phoenix
P-Shot 100 — Serving Greater Phoenix & Scottsdale
Beso Wellness & Beauty is one of the few clinics in the Phoenix area offering the P-Shot 100 as part of a comprehensive, medically supervised men’s sexual health program. We serve patients from across the greater Phoenix metro:
- North Phoenix (85050) — our clinic, near Desert Ridge Marketplace and Mayo Clinic
- North Scottsdale — 15 minutes via the 101
- Paradise Valley — direct access via the 51
- Arcadia and Central Scottsdale
- Glendale and Peoria
- Cave Creek, Fountain Hills, and greater Maricopa County
